Gozzadini is an Italian surname. Notable people with the surname include:
Angelo I Gozzadini (died between 1468 and 1476), Lord of Kythnos Angelo Gozzadini (1573–1653), Roman Catholic prelate Bettisia Gozzadini (1209–1261), Italian jurist Francesco Gozzadini (died 1673), Roman Catholic prelate Giovanni Gozzadini (1810–1887), Italian archaeologist Iakovos Gozadinos (1716–1786), Greek bishop of Gothia Marcantonio Gozzadini (1574–1623), Italian cardinal, cousin of Pope Gregory XV Maria Teresa Gozzadini (1812–1881), Italian geologist and countess Tommaso Gozzadini (1260–after 1329), Italian notary Ulisse Giuseppe Gozzadini (1650–1728), Italian cardinal and bishop of Imola