Fernando González was the defending champion but lost in the first round to Michal Tabara.
Andy Roddick won in the final 7–5, 6–3 against Hyung-Taik Lee.
Seeds A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
Jan-Michael Gambill (first round) Andrew Ilie (quarterfinals) Jérôme Golmard (semifinals) Michal Tabara (semifinals) Magnus Gustafsson (second round) Olivier Rochus (quarterfinals) Xavier Malisse (second round) Hyung-Taik Lee (final)
Draw
External links 2001 U.S. Men's Clay Court Championships Draw 2001 U.S. Men's Clay Court Championships Qualifying Draw