Iacono () is a surname of Italian origin. Notable people with the surname include:
Alessandro Iacono (born 1973), former Italian professional footballer David Iacono (born 2002), American actor Franck Iacono (born 1966), French freestyle swimmer Gianluca Iacono (born 1970), Italian voice actor Stanley Iacono, former mayor of Weehawken, NJ Maurizio Iacono, member of the Canadian rock band Kataklysm Norberto Iacono (1919–1985), Argentine footballer Paul Iacono, American actor Sal Iacono (born 1971), American comedian William Iacono, American psychologist
See also Iacona