Plakophilin are proteins of the cytoskeleton. They are involved in regulating the adhesive activity of cadherin.
The three types of plakophilin proteins found in humans are PKP1, PKP2, and PKP3; all exhibiting dual localization in the nucleus as well as desmosomes.
Genes include: PKP1 PKP2 PKP3
See also List of conditions caused by problems with junctional proteins
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