P65 may refer to:

Aldus PageMaker, discontinued desktop publishing software GRASP65, golgi reassembly stacking protein 1 Grumman XP-65, an American fighter aircraft design , a submarine of the Royal Navy P65 road (Ukraine) Papyrus 65, a biblical manuscript RELA, transcription factor p65 P65, a state regional road in Latvia Proposition 65, a California hazardous substance law. P65, three-dimensional space group number 170