Guillermo Vilas was the defending champion but did not compete that year.

José Luis Clerc won in the final 6–7, 2–6, 7–5, 6–0, 6–3 against Rolf Gehring.

Seeds A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.

n/a José Luis Clerc (champion) Víctor Pecci (semifinals) Hans Gildemeister (quarterfinals) Mario Martinez (second round) Rolf Gehring (final) Andrés Gómez (quarterfinals) Marcos Hocevar (second round)

Draw

Final

Section 1

Section 2

External links 1980 South American Championships singles draw