Guillermo Vilas was the defending champion but did not compete that year.
José Luis Clerc won in the final 6–7, 2–6, 7–5, 6–0, 6–3 against Rolf Gehring.
Seeds A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
n/a José Luis Clerc (champion) Víctor Pecci (semifinals) Hans Gildemeister (quarterfinals) Mario Martinez (second round) Rolf Gehring (final) Andrés Gómez (quarterfinals) Marcos Hocevar (second round)
Draw
Final
Section 1
Section 2
External links 1980 South American Championships singles draw