Big Branch is the name for many rivers and streams. If can also refer to:
Big Branch (Middle Fork Salt River tributary), a stream in Missouri Big Branch (Skull Lick Creek tributary), a stream in Missouri Big Branch (Haw River tributary), a stream in Alamance County, North Carolina Big Branch (Lanes Creek tributary), a stream in Anson County, North Carolina Big Branch (Crabtree Creek tributary), a stream in Wake County, North Carolina Big Branch Marsh National Wildlife Refuge Upper Big Branch Mine disaster