Charles Willoughby may refer to:
Charles Willoughby (politician) (1894–1995), member of Canadian Parliament Charles A. Willoughby (1892–1972), American military leader Charles Willoughby, 2nd Baron Willoughby of Parham (1536/7–1603), English peer Charles Willoughby, 10th Baron Willoughby of Parham (1650–1679), English peer Charles Willoughby, 14th Baron Willoughby of Parham (1681–1715), English peer
See also Charl Willoughby (born 1974), South African cricketer