Matanzima is a South African surname that may refer to George Matanzima (1918–2000), leader of Transkei, an area in South Africa and descendant of Ngubengcuka Kaiser Matanzima (1915–2003), leader of Transkei, an area in South Africa, brother of George and descendant of Ngubengcuka Lwandile Zwelenkosi Matanzima (1970/71–2010), South African clan leader and descendant of Ngubengcuka Qaqambile Matanzima (1949–2013), South Africa politician and tribal leader and descendant of Ngubengcuka Simphiwe Matanzima (born 1997), South African rugby union player Themba Matanzima (born 1953), South African Army officer