Milanese is a surname. Notable people with the surname include:
Alessandro Milanese, Italian motorcycle speedway rider Antonio Milanese (1912 – ?), Italian triple jumper Concetta Milanese (born 1962), Italian shot putter Gaetano Milanesi (1813–1895), Italian art historian Marco Milanese (born 1958), Italian archaeologist Marco Milanese (footballer) (born 1998), Italian footballer Mauro Milanese (born 1971), Italian footballer Rob Milanese (born 1980), American football wide receiver Tommaso Milanese (born 2002), Italian footballer Víctor Milanese Comisso (born 1959), Argentine footballer and manager