PORCN (porcupine homolog – Drosophila) is a human gene. The protein is homologous to other membrane-bound O-acyltransferases.
Function The protein encoded by this gene is an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A. It performs O-Palmitoleoylation of these proteins.
Clinical significance Mutations in this gene are associated with focal dermal hypoplasia.
Mutations in PORCN are associated to Goltz-Gorlin syndrome.
Ligands Inhibitors WNT974 (LGK-974) - 1243244-14-5, researched for anti-cancer effects in Wnt-pathway sensitive tumours. Also investigated for influencing cardiac tissue remodelling following infarction.
IWP (1-4)
RXC004
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