Francesco Mancini may refer to:
Francesco Mancini (footballer, born 1968) (1968–2012), Italian footballer Francesco Mancini (footballer, born 1990), Italian footballer Francesco Mancini (1679–1758), Italian painter Francesco Mancini (1830–1905), Italian painter Francesco Longo Mancini (1880–1954), Italian painter
Other Francesco Maria Mancini (1606–1672), Italian cardinal Francesco Mancini (composer) (1672–1737), Italian baroque composer from Naples