Spencer House may refer to:
Spencer House, Westminster, Greater London, England
United States Spencer House (Hartford, Connecticut), listed on the National Register of Historic Places (NRHP) in Hartford County Spencer House in Columbus, Georgia, former home of educator William Henry Spencer Spencer House (Lima, New York), listed on the NRHP in Livingston County Spencer House (Syracuse, New York), listed on the NRHP in Onondaga County Arthur Champlin Spencer and Margaret Fenton Spencer House, Portland, Oregon, listed on the NRHP in Multnomah County Spencer–Shippee–Lillbridge House, East Greenwich, Rhode Island, listed on the NRHP in Kent County William B. Spencer House, West Warwick, Rhode Island, listed on the NRHP in Kent County Spencer House (Bishopville, South Carolina), listed on the NRHP in Lee County Spencer House (Cincinnati), a hotel from 1853 to 1935