De Medina is a surname. Notable people with the surname include:
Bartolomé de Medina (theologian) (1527–1581), Spanish theologian Eduardo Diez de Medina (1881–1955) Federico Diez de Medina (1839–1904) Juan de Medina (1490–1547) Lucila Gamero de Medina (1873–1964) Miguel de Medina (1489–1578) Nathan de Medina (born 1997), Belgian footballer Samuel de Medina (1505–1589) Solomon de Medina (1650–1730)
See also
Medina