Șișești is a commune located in Mehedinți County, Oltenia, Romania. It is composed of six villages: Cărămidaru, Ciovârnășani, Cocorova, Crăguești, Noapteșa, and Șișești.
Natives (born 1949), politician Gheorghe Ionescu-Sisești (1885–1967), agronomer, titular member of the Romanian Academy (1888–1954), physician and academic, corresponding member of the Romanian Academy
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