D'Alessio is an Italian surname. Notable people with the surname include:
Andrés J. d'Alessio (1940–2009), Argentine academic Carlos d'Alessio (1935–1992), French composer Charlotte D'Alessio (born 1998), Canadian model Corrie D'Alessio (born 1969), Canadian ice hockey player Ernesto D'Alessio (born 1977), Mexican actor Gigi D'Alessio (born 1967), Italian pop singer and songwriter Jillian D'Alessio (born 1985), Canadian kayaker Lupita D'Alessio (born 1954), Mexican singer and actress Ugo D'Alessio (1909–1979), Italian film actor
D'Alesio Donald D'Alesio, American football coach