Bettini is a surname of Italian origin. Notable people with the surname include:
Alessandro Bettini (1821–1898), Italian tenor involved in the UK legal case of Bettini v Gye Amalia Bettini (1809–1894), Italian stage actress Antonio Bettini (1396–1487), Italian clergyman and writer Carlos Bettini (born 1951), Argentinian businessman, politician, and diplomat Décimo Bettini (1910–1982), Italian racing cyclist Domenico Bettini (1644–1705), Italian painter of the Baroque era Gianni Bettini (1860–1938), Italian-American builder of phonographs Goffredo Bettini (born 1952), Italian politician, founding member of the Democratic Party (PD) Gonzalo Bettini (born 1992), Argentine footballer Lorenzo Bettini (1931–2008), Italian professional football player Mariano Bettini (born 1996), Argentine professional footballer Mario Bettini (1582–1657), Italian Jesuit philosopher, mathematician and astronomer Maurizio Bettini (born 1947), Italian philologist, anthropologist and novelist Paolo Bettini (born 1974), Italian road-racing bicyclist Pietro Bettini (fl. 17th century), Italian engraver of the Baroque era Sergio Bettini (1905–1986), Italian art historian Thomas Bettini, former member of American rock band Jackyl Virginio Bettini (1942–2020), Italian politician Zelia Trebelli-Bettini (1838–1892), French opera singer