S66 may refer to: S66 (Long Island bus) S66 (New York City bus) serving Staten Island Island Awabakal language Daihatsu Hijet (S66), a Japanese kei truck Explorer S-66, a failed American spacecraft Savoia-Marchetti S.66, an Italian flying boat S66, a postcode district for Rotherham, England Siemens S66, a Siemens mobile phone Homedale Municipal Airport (ICAO Code S66) in Homedale, Idaho