S28 may refer to:
Aviation Blériot-SPAD S.28, a French long-distance biplane International Peace Garden Airport in Rolette County, North Dakota Letov Š-28, a Czechoslovak reconnaissance biplane Sikorsky S-28, a proposed French biplane bomber
Rail S28 (Rhine-Ruhr S-Bahn), a service in Germany S28, an Aargau S-Bahn service in Switzerland
Roads County Route S28 (California) New Jersey Route 18, partially designated S28 until 1953 Northern Airport Expressway, China
Science 40S ribosomal protein S28 British NVC community S28, a swamps and tall-herb fens community in the British National Vegetation Classification system S28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer), a safety phrase Sulfur-28, an isotope of sulfur
Other uses , a submarine of the Royal Navy Mena Station, in Rankoshi, Isoya District, Hokkaido, Japan SREC (file format), an ASCII encoding format for binary data , a submarine of the United States Navy