James Byrnes may refer to:
James Byrnes (Australian politician) (1806–1886), New South Wales politician James Byrnes (sailor) (1838–1882), Irish sailor and Medal of Honor recipient James F. Byrnes (1882–1972), American politician and South Carolina Supreme Court justice Jim Byrnes (baseball) (1880–1941), American baseball player Jim Byrnes (actor) (born 1948), American actor and blues musician
See also James Burns (disambiguation) James Burnes (disambiguation) James Byrne (disambiguation)