James Nichols may refer to:
James D. Nichols (1928–2003), American jockey James Nichols, convicted for the 2007 murder of Cha Vang in Wisconsin James P. Nichols, recording industry producer and engineer James Nichols (printer) (1785–1861), English printer and theological writer James Edward Nichols (1902–1972), Welsh geneticist James Douglas Nichols (1954–2017), American farmer, brother of Terry Nichols, convicted Oklahoma City Bombing accomplice James W. Nichols (born 1946), American farmer and politician
See also James Nicholls (disambiguation) Jim Nickalls (1934–2016), English football centre-half for Darlington