The Chicago, Milwaukee, St. Paul and Pacific Railroad Depot in Aberdeen, South Dakota was built by the Chicago, Milwaukee, St. Paul and Pacific Railroad (also known as The Milwaukee Road) in 1911.

The depot is rectangular in shape, two stories, and is built of brick and concrete. Its style reflects the Craftsman/Prairie influences of the early 20th century. It was built to replace an earlier wooden depot that burned. Aberdeen served as a division point on the Milwaukee Road and the upper floors of the depot contained railroad offices. In its heyday the station served the Milwaukee Road's Olympian Hiawatha, which ran from Chicago to Seattle and Tacoma.The Olympian Hiawatha schedule https://www.streamlinerschedules.com/concourse/track7/olympianhi195607.html Passenger trains last served the station for Minneapolis on April 17, 1969.Kevin Bennett, "Man working to bring passenger trains back to Aberdeen" Aberdeen News, November 6, 2011 http://articles.aberdeennews.com/2011-11-06/news/30371888_1_passenger-train-train-service-ted-kneebone "Aberdeen, S.D., railway laying tracks into the future" R, T & S, July 21, 2009 http://www.rtands.com/index.php/news/aberdeen-sd-railway-laying-tracks-into-the-future.html

The depot is the largest brick passenger depot still standing in South Dakota. It was listed in the National Register due to its architecture and association with the development of railroads in South Dakota.

The building was bought by an investment company that leases office space. The basement of the depot houses a model railroad club.

References French, Edith. Chicago, Milwaukee, St. Paul and Pacific Railroad Depot (Brown County, South Dakota) National Register of Historic Places Inventory-Nomination Form, 1977. On file at the National Park Service.