Opdyke may refer to:
Surname David Opdyke, (born 1969), American visual artist Irene Gut Opdyke (1922–2003), Polish nurse, a Righteous Amongst the Nations George Opdyke (1805–1880), American entrepreneur, New York City mayor Neil D. Opdyke (1933–2019), American professor William Opdyke (born 1950s), American scientist
Places Opdyke, Illinois Opdyke West, Texas
See also
Opdycke, a surname Updike, a surname