Samułki Duże is a village in the administrative district of Gmina Wyszki, within Bielsk County, Podlaskie Voivodeship, in north-eastern Poland.
According to the 1921 census, the village was inhabited by 175 people, among whom 168 were Roman Catholic, 1 Orthodox, and 6 Mosaic. At the same time, 168 inhabitants declared Polish nationality, 1 Belarusian and 6 Jewish. There were 31 residential buildings in the village.Skorowidz miejscowości Rzeczypospolitej Polskiej: opracowany na podstawie wyników pierwszego powszechnego spisu ludności z dn. 30 września 1921 r. i innych źródeł urzędowych., t. T. 5, województwo białostockie, 1924, s. 30.
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