de Michelis (or alternate spellings Demichelis, Demicheli) may refer to:

Adriano de Micheli (born 1975), Italian auto racing driver Giovanni De Micheli, electrical engineer and educator Maria Pierina De Micheli (1890–1945), Italian Roman Catholic religious sister Mario De Micheli (born 1906), Italian footballer Paola De Micheli (born 1973), Italian politician Cesare G. De Michelis (born 1944), professor of Russian literature at the University of Rome Elizabeth De Michelis, scholar of modern yoga Eurialo De Michelis (1904–1990), Italian writer Gianni De Michelis (1940–2019), Italian politician Martín Demichelis (born 1980), Argentine football manager and former player Alberto Demicheli (1896–1980), Uruguayan politician Tulio Demicheli (1914–1992), Argentine film director Sofía Álvarez Vignoli de Demicheli (1899–1986), First Lady of Uruguay

See also