The 2000–01 Campionato Sammarinese di Calcio season was the 16th season since its establishment. It was contested by 15 teams, and S.S. Cosmos won the championship.
Regular season
Group A
Group B
Results All teams play twice against the teams within their own group and once against the teams from the other group.
Championship playoffs
First round
Second round
Third round
Fourth round
Semifinal
Final
References San Marino - List of final tables (RSSSF)