Șieu-Odorhei (; ) is a commune in Bistrița-Năsăud County, Transylvania, Romania. It is composed of seven villages: Agrișu de Jos (Alsóegres), Agrișu de Sus (Felsőegres), Bretea (Breit; Magyarberéte), Coasta (Sajókiskeresztúr), Cristur-Șieu (Oberkreuz; Bethlenkeresztúr), Șieu-Odorhei, and Șirioara (Sajósárvár).

The commune is situated on the Transylvanian Plateau, at an altitude of , on the banks of the Șieu River. It is located in the west-central part of Bistrița-Năsăud County, east of the town of Beclean and west of the county seat, Bistrița.

At the 2011 census, there were 2,262 inhabitants, of which 91.1% were Romanians and 8.3% Hungarians. At the 2021 census, Șieu-Odorhei had a population of 2,219; of those, 88.2% were Romanians and 4.8% Hungarians.

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