James Tyrrell (c. 1450–1502) was the alleged murderer of the Princes in the Tower.
James Tyrrell may also refer to: James Tyrrell (writer) (1642–1718), English author and political philosopher James Tyrrell (British Army officer) (c. 1674–1742), MP for Boroughbridge James Robert Tyrrell (1875–1961), Australian bookseller, art dealer, publisher and author James William Tyrrell, Canadian topologist and author James Tyrrell (Canadian football) (born 1996), Canadian gridiron football player