Manuel Aguirre may refer to:
Manuel Aguirre, 20th-century Mexican general and leader of the Escobarista rebellion Manuel Aguirre de Tejada (1827–1911), Spanish politician Manuel Aguirre Geisse, Minister of Health of Chile for three weeks in February 1950 Manuel Aguirre y Monsalbe (1822–1856), Spanish painter Manuel Aguirre (rugby union) (born 1959), Argentine rugby union player Manuel Bernardo Aguirre (1908–1999), Mexican politician Manuel Aguirre, a character in Rebelde Way, an Argentine telenovela Manuel Aguirre, a Jesuit missionary to New Spain Manuel Aguirre (1904–1969), Spanish Jesuit