Agache is a surname. Notable people with the surname include:
Alexandru Agache (born 1955), Romanian baritone Alfred Agache (architect) (1875–1959), Brazilian urban planner Alfred Agache (painter) (1843–1915), French painter Angel Agache (born 1976), Moldovan politician Dragoș Agache (born 1984), Romanian swimmer Lavinia Agache (born 1968), Romanian gymnast Roger Agache (1926–2011), French archaeologist
Agache may also refer to: A tributary of the Sensée in northern France
See also Agacher Strip War, border dispute between Burkina Faso and Mali - similar name