Santa Eufemia may refer to:
Santa Eufemia, Spain Santa Eufemia del Barco, Spain Santa Eufemia del Arroyo, Spain Sant'Eufemia d'Aspromonte, Reggio Calabria, Italy Sant'Eufemia a Maiella, Italy Santa Eufemia, Argentina, in Juárez Celman Department Gulf of Saint Euphemia, Italy
See also Euphemia, the Christian saint after whom all of the above were named Eufemia (disambiguation) Sant'Eufemia (disambiguation)