The 2005–06 European Challenge Cup was the tenth year of the European Challenge Cup, the second tier rugby union cup competition below the Heineken Cup. The tournament was held between October 2005 and May 2006.
Group stage
Pool 1 TeamPWDLTries forTries againstTry diffPoints forPoints againstPoints diffTBLBPts Northampton Saints650132122019496985025 Narbonne640216115125113122018 Bristol630326215203150533116 Viadana6006939−3081244−163011
Pool 2 TeamPWDLTries forTries againstTry diffPoints forPoints againstPoints diffTBLBPts London Irish6600321121239811583027 Agen630323158163143203014 Pau62041219−7107153−462111 Overmach Parma6105830−2274206−132004
Pool 3 TeamPWDLTries forTries againstTry diffPoints forPoints againstPoints diffTBLBPts Gloucester660049643331532785029 Bayonne6402311120202931094020 București6105740−3371253−182015 Toulon6105939−3064269−205015
Pool 4 TeamPWDLTries forTries againstTry diffPoints forPoints againstPoints diffTBLBPts Newcastle Falcons6600441034324812434028 Brive6303301911203169344218 Borders63031923−4155177−222115 L'Aquila60061455−41103358−255011
Pool 5 TeamPWDLTries forTries againstTry diffPoints forPoints againstPoints diffTBLBPts Worcester Warriors6501241212181103783125 Connacht6402251411190119713120 Catania62041541−26116257−141118 Montpellier610526233170178−8227
Seeding and runners-up SeedPool WinnersPtsTF+/-1 Gloucester2949+2782 Newcastle Falcons2844+2433 London Irish2732+1584 Northampton Saints2532+985 Worcester Warriors2524+78 SeedPool Runners-upPtsTF+/-6 Bayonne2031+1097 Connacht2025+718 Brive1830+34 – Narbonne1816+12 – Agen1416+20
Knockout stage
Quarter-finals
Semi-finals
Final
See also European Challenge Cup 2005–06 Heineken Cup