Drane is a surname. Notable people with the surname include:
Augusta Theodosia Drane (1823–1894), English writer and Roman Catholic nun Ashley Drane (born 1981), American film and television actress Dwight Drane (born 1962), American football player Herbert J. Drane (1863–1947), American politician James Drane (1808–1869), American politician John Drane, theologian