The First Division Knock-Out was a football competition contested by teams playing in the Maltese First Division. The competition was introduced for the 2006–07 season. There were four teams who compete in a preliminary round, with the two winners advancing to the quarter-finals with six other teams. The competition was continued in a knockout fashion.
Winners SeasonWinnersScoreRunners–up2006–07Tarxien Rainbows2–1Mosta2007–08Dingli Swallows3–1Vittoriosa Stars2008–09St. Patrick2–0Dingli Swallows2009–10Marsaxlokk1–0St. George's2010–11Dingli Swallows3–2Balzan Youths