Ascani is a surname. Notable people with the surname include:
Francesco Ascani (born 1952), Italian racing driver Franco Ascani (born 1943), Italian businessman and sports manager Anna Ascani (born 1987), Italian politician Fred Ascani (1917–2010), American aviator and United States Air Force general Luca Ascani (born 1983), Italian cyclist Pellegrino Ascani, Italian Renaissance painter