Cow Creek may refer to:

Places in the United States Cow Creek, Kentucky Cow Creek, South Dakota Cow Creek, a CCC camp in Death Valley National Park later used as a detention facility for Japanese Americans in WWII

Streams and rivers in the United States Cow Creek (Sacramento River tributary), California Cow Creek (Kansas) Cow Creek (Montana), a tributary of the Missouri River Cow Creek (Jordan Creek), Oregon Cow Creek (South Umpqua River), a stream in southern Oregon Cow Creek (Washington), a river in Washington

Other uses Cow Creek Band of Umpqua Tribe of Indians, a Native American tribe from the Cow Creek area of Oregon Cow Creek Skirmish, a minor American Civil War skirmish in Pittsburg, Kansas