The Big Question may refer to: The Big Question (comics), a.k.a. Enigma Fisk, a fictional character in Amalgam Comics The Big Question (TV series), a five-part television series exploring the evolution of the universe and life, broadcast on Channel 5 in 2004 and 2005 The Big Question (novel), a 2007 novel by Chuck Barris
See also The Big Questions, a panel discussion TV series on faith and ethics broadcast on the UK's BBC One starting in September 2007