JAML or Junctional Adhesion Molecule-Like, or AMICA1 is a JAM transmembrane protein family member. Other members of the JAM family of transmembrane proteins include JAM1, JAM2 and JAM3.
Tissue distribution
It has been shown to localize to the tight junctions of epithelial cells.
Structure
It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling.
Function
It is a known ligand of JAML is Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice).
JAML-mediated activation of CAR is required for neutrophil extravasation in addition to other leukocyte/epithelial cell interaction models.
References
Further reading