Ditolylguanidine (DTG) is a sigma receptor agonist. It is somewhat selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. It has neuroprotective and antidepressant effects, and potentiates the effects of NMDA antagonists.
Properties N,N′-Di-o-tolylguanidine is a flammable, white solid that is practically insoluble in water. It decomposes upon heating, potentially releasing nitrogen oxides, carbon monoxide, and carbon dioxide.
Safety Information N,N′-Di-o-tolylguanidine is not itself carcinogenic, but due to the manufacturing process, it may still contain o-toluidine, which is carcinogenic. Therefore, if the o-toluidine content exceeds 0.1 percent, the mixture should be considered carcinogenic.
See also Aptiganel
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