Agrest is a surname. Notable people with the surname include:
Diana Agrest (born 1945), US-Argentinian architect Evgeny Agrest (born 1966), Belarusian-Swedish chess grandmaster Matest M. Agrest (1915–2005), Russian ethnologist and mathematician Mikhail Agrest, Russian conductor
Fictional Adrien Agreste and his father, Gabriel Agreste, from Miraculous: Tales of Ladybug & Cat Noir (French animated TV series)