Atypical chemokine receptor 5 is a protein which in humans is encoded by the gene ACKR5 (previously GPR182). It is an atypical G-protein coupled receptor. It functions to regulate chemokine levels by sequestering its ligands: CXCL13 and CCL28.
When this gene was first cloned, it was proposed to encode an adrenomedullin receptor. However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).
It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.
See also Duffy antigen system (ACKR1) Atypical chemokine receptor 2 Atypical chemokine receptor 3 Atypical chemokine receptor 4
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