William Humphrey may refer to:
William Humphrey (engraver) (1740–1810), English printseller William Humphrey (cricketer) (1843–1918), English cricketer William Humphrey (writer) (1924–1997), American novelist William Humphrey (Northern Ireland politician) (born 1967), Northern Irish unionist William E. Humphrey (1862–1934), American politician William F. Humphrey (1860–1928), Canadian politician in the Legislative Assembly of New Brunswick William J. Humphrey (1875–1942), film director Willie Humphrey (1900–1994), jazz clarinetist William Humfrey (died 1579), mining promoter, Assay Master at the Royal Mint
See also William Humphreys (disambiguation)