Macomb is a surname that may refer:
Alexander Macomb (merchant) (1748–1831), Irish-American merchant and land speculator, father of Alexander Macomb Alexander Macomb (general) (1782–1841), commanding general of the U.S. Army (1828–1841) David B. Macomb (1827–1911), U.S. Navy rear admiral and engineering officer during the American Civil War, grandson of merchant William Macomb John Navarre Macomb Jr. (1811–1889), U.S. Army topographical engineer, explorer of the Colorado River, U.S. Army colonel and nephew of Major General Alexander Macomb Montgomery M. Macomb (1852–1924), U.S. Army brigadier general, son of John Navarre Macomb Jr. William Macomb (1751–1796), Irish-British fur trader, merchant and landowner in Detroit, member of first parliament of Upper Canada, brother of merchant Alexander Macomb William H. Macomb (1819–1872), American Civil War naval officer, son of Major General Alexander Macomb
See also McComb (surname) Macome, a surname Macomber (disambiguation)