Agnello () is an Italian surname literally meaning "lamb". Notable people with the surname include:
Bruno Agnello (born 1985), Brazilian football midfielder Carmine Agnello (born 1960), American mobster Carmine Gotti Agnello (born 1986) American reality television participant Chris Agnello (born 1968), American soccer coach Frank Gotti Agnello (born 1990), American reality television participant Giovanni Battista Agnello, Venetian author and alchemist John Gotti Agnello (born 1987), American reality television participant Louis "Cousin Vinny" Agnello, American writer Vincenzo Agnello Suardi (1582–1644), Roman Catholic prelate who served as Bishop of Mantua and Alba
See also Agnelli