Giant-killing or giant killer may refer to:
Killing a literal giant, such as: Gigantomachy, a Greek mythological battle David and Goliath, a biblical story "Jack the Giant Killer", a Cornish fairy tale and legend Upset (competition), the victory of underdog over a favourite (or top dog) Giant Killing, a Japanese manga series by Masaya Tsunamoto and Tsujitomo Giant Killer (call sign), an American military aviation call sign "Giant Killer" (story), a 1945 short story by A. Bertram Chandler Giantkiller, a DC Comics limited series
See also Giant Killers (disambiguation) Jack the Giant Killer (disambiguation)