Phryne was a famous courtesan of Ancient Greece. Sometimes also Phryné in English.

Phryne may also refer to: Phryné (opera), an 1893 opéra comique by Camille Saint-Saëns Phryne (painting), an 1867 painting by Artur Grottger 1291 Phryne, a main-belt asteroid Phryne Fisher, a fictional detective Phryne , synonym for Sisymbrium