4-Hydroxy-3-methylbut-2-enyl diphosphate reductase

4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (, isopentenyl-diphosphate:NADP+ oxidoreductase, LytB, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase, HMBPP reductase, IspH, LytB/IspH) is an enzyme in the non-mevalonate pathway. It acts on (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP).

The enzyme characterised from Zymomonas mobilis and Plasmodium falciparum gives a mixture of dimethylallyl pyrophosphate and isopentenyl pyrophosphate in the ratio of five to one.

4-Hydroxy-3-methylbut-2-enyl diphosphate reductase is an iron-sulfur protein that contains an unusual [4Fe-4S] cluster.

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