Marchisio () is an Italian surname, particularly common in Piedmont. Notable people with the surname include:
Claudio Marchisio (b. 1986), Italian footballer Juvenal P. Marchisio (1902–1973), American lawyer, judge and president of American Relief for Italy Luigi Marchisio (1909–1992), Italian cyclist Rita Marchisio (b. 1950), Italian runner Rosina Lawrence Marchisio (1912–1997), Canadian-American actress
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