Yepes is a surname. Notable people with the name include:
Gerard Yepes (born 2002), Spanish footballer Linda Yepes (born c. 1988), Colombian television presenter Mario Yepes (born 1976), Colombian footballer Narciso Yepes (1927–1997), Spanish guitarist Tomás de Yepes (c. 1595–1674), Spanish painter Juan de Yepes y Álvarez (1542–1591), birth name of John of the Cross, Spanish mystic, Catholic saint, Carmelite friar and priest
See also Yepes, Spanish town Yepez