Unica may refer to:
People Abbas Ali Atwi (born 1984), Lebanese football player, also known as Onika (also spelled Unica) Unica Zürn (1916–1970), German author and artist
Education Network of Universities from the Capitals of Europe ("institutional network of the UNIversities from the CApitals of Europe") University of Ciego de Ávila, in Ciego de Ávila, Cuba University of Cagliari (), in Cagliari, Sardinia, Italy
Music Unica (La India album), 2010 Unica (Ornella Vanoni album), 2021
Other uses Unica (material), a vulcanised lump paper material Unica (river), a karst river of Slovenia Unica (typeface) UNICA, Brazil (União da Indústria de Cana-de-Açúcar), an association of producers of sugarcane and ethanol fuel in Brazil Unica Corporation, an American manufacturer of enterprise marketing management software Union and Change, a political party in Venezuela Mateba Model 6 Unica, an Italian handgun
See also Unitsa, a Russian village